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| 內容簡介： |
《药物化学实验双语教程Experiments of Medicinal
Chemistry》按照从基础操作到综合实验的顺序安排了10个经典化学药物合成实验，强调了药物化学理论教学与实验的关联，关注学生实验能力和科研素质的培养。附录包含实验报告模板、常规仪器和思考题参考答案三部分内容。
《药物化学实验双语教程Experiments of Medicinal Chemistry》可作为高等医药院校药学类专业学生包括留学生的实验教材，也可供其他药学相关专业从业人员参考使用。
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| 關於作者： |
李雯，郑州大学药学院，硕导 正高，2010年获批为河南省中青年骨干教师，2012年通过教授职称评审，现为中国药学会河南省分会药物化学专业委员会委员，河南省药审中心审评专家，河南省科技厅项目评审专家，Applied Catalysis A：General, Bioorganic & Medicinal Chemistry
Letters, 郑州大学学报等杂志审稿人，先后主持或参与国家自然科学基金、河南省重点科技攻关项目、河南省自然科学基金项目等多项；发表科研论文40余篇，其中，SCI、EI收录20篇；获授权国家发明专利9项；省级科技成果鉴定6项；多次获各项科技成果奖励。
此外，具有12年本科生药物化学课程与实验教学经历，先后获河南省教学成果奖二等奖（主持），郑州大学教学成果奖一等奖等教学方面的奖励。
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| 目錄：
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Experiment 1 Recrystallization of
Acetanilide1
实验一乙酰苯胺重结晶7
Experiment 2 Synthesis of Aspirin12
实验二阿司匹林的合成17
Experiment 3 Synthesis of Paracetamol22
实验三扑热息痛的合成27
Experiment 4 Synthesis of Benorilate31
实验四苯乐来的合成37
Experiment 5 Synthesis of Sulfacetamide Sodium42
实验五磺胺醋酰钠的合成49
Experiment 6 Synthesis of Benzocaine55
实验六苯佐卡因的合成64
Experiment 7 Synthesis of Ciprofloxacin Monohydrochloride Monohydrate71
实验七盐酸环丙沙星的合成81
Experiment 8 Synthesis of Phenytoin Sodium89
实验八苯妥英钠的合成95
Experiment 9 Synthesis of Neostigmine Bromide100
实验九溴新斯的明的合成107
Experiment 10 Synthesis of Dyclonine Hydrochloride113
实验十盐酸达克罗宁的合成119
Appendix 1 Experimental Report Template124
附录一实验报告模板127
Appendix 2 Reference Answer for the Discussion Questions130
附录二思考题参考答案135
Appendix 3 Common Instruments（常用仪器）140
References（参考文献）142
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| 內容試閱：
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为适应我国本科教学国际化的发展趋势，根据药物化学实验课程的基本要求，结合我们多年的教学经验和科研工作，编写了这本《药物化学实验双语教程Experiments of Medicinal Chemistry》。
本书包括10个化学药物合成实验，实验一至实验八为我们多年药物化学实验教学实践的总结，实验九和实验十为编者科研工作的结果。在化学药物合成实验的安排上，本书按照从基础操作到综合实验的顺序进行编写；在内容上，本书不仅给出了实验原理、操作过程、注意事项和思考题，而且给出了药物分子和靶标的作用机制图示、主要原料和中间体的物理常数、实验装置、安全提示和思考题参考答案。旨在强调药物化学理论教学与实验的关联，关注学生实验能力和科研素质培养。10个化学药物合成实验的难易程度和实验学时有明显的区分度，可满足不同专业和不同层次学生的教学需求。
本教材的实验一、实验二、实验七、实验九由李雯、刘宏民编写，实验三、实验四由陈亚静编写，实验五由丁丽娜编写，实验六由张恩编写，实验八由郑一超编写，实验十由张秋荣编写，全书由尤启冬教授审订。书中药物分子和靶标的作用机制部分由丁丽娜及其研究生阎影、马超亚、王志正、高琦冰、孙旭东和杨晶等借助MOE软件进行模拟研究编写而成。留学中国的博士研究生Moges Dessale
Asmamaw、研究生常英杰、李瑞鹏及本科生朱林元参与了本书的语言润色工作。药物化学实验双语教材的建设，任重而道远。
《药物化学实验双语教程Experiments of Medicinal Chemistry》采用中英双语体系编写，可作为普通高等医药院校药学类各专业学生（包括留学生）的实验教材，也可供其他药学相关专业师生参考使用。
编者
2019年3月
In order to adapt to the development trend of internationalization of
undergraduate teaching in our country, according to the basic requirements of
pharmaceutical chemistry experiment course combined with our years of teaching
experience and scientific research work, this bilingual
course of pharmaceutical chemistry experiment has been
compiled.
In this textbook, 10 synthetic experiments of chemical drugs are
included.Experiments 1 through 8 are the summaries of many years teaching
practices, Experiments 9 and 10 are the results of the editors scientific research work.They are arranged by the order from basic
to comprehensive gradually.In each experiment, more than the experiment
principle, operation process, notes and discussion questions are given, the
action mechanism diagrams of drug molecule and target, physical constants of
key raw materials and intermediates, experimental equipments, safety tips and
reference answers of discussion questions are described.This textbook
emphasizes the relationship between theoretical teaching and experiment of
pharmaceutical chemistry, and pays attention to the cultivation of students experimental ability and scientific research quality.There is a
clear distinction between the difficulty and time of 10 experiments to meet the
teaching needs of students from different majors and levels.
Experiments 1, 2, 7 and 9 of this textbook were written by Wen Li and Hongmin
Liu, Experiments 3 and 4 by Yajing Chen, Experiment 5 by Lina Ding, Experiment
6 by En Zhang, Experiment 8 by Yichao Zheng and Experiment 10 by Qiurong
Zhang.This textbook was revised by Professor Qidong You.The mechanistic studies
between the drug molecule and the corresponding target were investigated and
written by Lina Ding and her graduate students Ying Yan, Chaoya Ma, Zhizheng
Wang, Qibing Gao, Xudong Sun and Jing Yang with the help of MOE software.We
appreciate the foreign PhD student Moges Dessale Asmamaw, graduate students
Yingjie Chang, Ruipeng Li and undergraduate student Linyuan Zhu who involved in
the language correction of this textbook.The construction of bilingual
textbooks is on the developing way.
This textbook is compiled in a Chinese-English bilingual system and can be used
in the experimental teaching of pharmaceutical students including foreign
students in medical colleges and universities.
Editors
March 2019
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