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本教材为留学生临床医学专业用教材系列之一，原版引进改编，国内*本。
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| 內容簡介： |
每年来华的医学留学生人数增加，招生量扩大，留学生用的性价比合适的教材需求越来越迫切。而现在没有全国性编写的成套教材可供选择，出版后对教育部系列教材建设是一个完善和补充，对参编院校的理论建设教材体系也是一个契机和提升。
随着核医学显像设备SPECT及PET的逐步普及应用，核医学与临床各学科的关系日趋密切。核医学分子影像成为影像诊断中不可或缺的部分。该教材除了注重核医学基础理论、基本技术及核医学在各系统的临床应用外，重点按系统编写，内容主要根据临床实用与需要考虑。为加深学生对核医学影像的认识和理解，精选大量原始彩色插图，深入浅出，让读者易懂易学。此外，也突出了核素治疗在临床核医学中的重要地位，体现出临床核医学是一门诊断与治疗并重的学科。
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| 關於作者： |
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谭建、教授、博士研究生导师，核医学科主任，核医学教研室主任。现任中华医学会核医学分会常委，中华医学会核医学分会肿瘤学组组长。中国医师协会核医学医师分会常委，中国医师学会核医学医师分会医师培训与考核委员会副主任。中国影像技术研究会核医学分会副主任委员。天津医学会核医学分会主委。
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| 目錄：
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Contents
目.录
PartⅠ Basic Principles
Chapter 1 Physics of Nuclear Medicine
........................................................................................................................
3
RADIoACTIvITY AND RADIoACTIvE DECAY
.............................................................................................................
3
INTERACTIoNS BETWEEN RADIATIoN AND MATTER
............................................................................................
7
SUGGESTED READING
.......................................................................................................................................................
12
Chapter 2 Radiopharmaceuticals
..................................................................................................................................
13
ElEMENTS, RADIoNUClIDES, AND
RADIoPHARMACEUTICAlS
...................................................................... 13
PRoDUCTIoN oF RADIoNUClIDES
..............................................................................................................................
14
RADIoNUClIDE GENERAToRS
......................................................................................................................................
15
TECHNETIUM CHEMISTRY AND RADIoPHARMACEUTICAl
PREPARATIoN ................................................ 16
QUAlITY ASSURANCE oF TECHNETIUM-99MlABElED
RADIoPHARMACEUTICAlS ............................. 16
SINGlE-PHoToN RADIoPHARMACEUTICAlS oTHER
THAN TC-99M .............................................................. 17
DUAl PHoToN RADIoPHARMACEUTICAlS FoR
PoSITRoN EMISSIoN ToMoGRAPHY ........................... 18
DISPENSING RADIoPHARMACEUTICAlS
...................................................................................................................
18
SUGGESTED READING
.......................................................................................................................................................
19
Chapter 3 Radiation Detection and
Instrumentation ..........................................................................................
20
CHARATERISTICS oF A RADIATIoN DETECToR
......................................................................................................
20
TYPES oF RADIATIoN DETECToRS
...............................................................................................................................
21
ANCIllARY EQUIPMENT
.................................................................................................................................................
22
NUClEAR MEDICINE IMAGING
.....................................................................................................................................
23
SUMMARY .............................................................................................................................................................................
27
SUGGESTED READING
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28
Chapter 4 Single-Photon Emission Computed
Tomography, Positron Emission Tomography, and Hybrid Imaging
......................................................................................................................................
29 IMAGE RECoNSTRUCTIoN
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29 SINGlE-PHoToN EMISSIoN CoMPUTED ToMoGRAPHY
.....................................................................................
35 PoSITRoN EMISSIoN ToMoGRAPHY
...........................................................................................................................
35 HYBRID PoSITRoN EMISSIoN CoMPUTED ToMGRAPHY, SINGlEPHoToN CoMPUTED
ToMoGRAPHY WITH CoMPUTED ToMoGRAPHY, AND PoSITRoN EMISSIoN ToMoGRAPHY WITH
MAGNETIC RESoNANCE
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36 SUGGESTED READING
.......................................................................................................................................................
37
Chapter 5 Molecular Imaging .........................................................................................................................................
38
IMAGING TECHNIQUES
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38
BIoMARkERS
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39
REPoRTER GENE IMAGING AND GENE THERAPY
...................................................................................................
42
SUGGESTED READING
.......................................................................................................................................................
43
Part Ⅱ Clinical Nuclear
Medicine
Chapter 6 Central Nervous System
..............................................................................................................................
47
CEREBRAl ANAToMY
.......................................................................................................................................................
47
CEREBRAl BlooD FloW AND METABolISM
...........................................................................................................
48
ClINICAl APPlICATIoNS FoR CEREBRAl
PERFUSIoN IMAGING
..................................................................... 51
MovEMENT DISoRDERS
...................................................................................................................................................
62
AMYloID IMAGING
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63
CISTERNoGRAPHY
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64
SUGGESTED READING
.......................................................................................................................................................
68
Chapter 7 Cardiac System
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69
MYoCARDIAl PERFUSIoN SCINTIGRAPHY
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69
PoSITRoN EMISSIoN ToMoGRAPHY oF THE HEART
............................................................................................
97
RADIoNUClIDE vENTRICUloGRAPHY
....................................................................................................................
104
MYoCARDIAl INFARCT AND AMYloIDoSIS IMAGING
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111
SUGGESTED READING
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111
Chapter 8 Endocrine System
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113
THYRoID SCINTIGRAPHY AND UPTAkE STUDIES
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113
PARATHYRoID SCINTIGRAPHY
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121
SUGGESTED READING
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124
Chapter 9 Oncology： Positron Emission
Tomography
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125
BACkGRoUND
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125
IMAGE INTERPRETATIoN
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127
ClINICAl USES oF PoSITRoN EMISSIoN
ToMoGRAPHY IN oNColoGY .................................................... 134
SUGGESTED READING
.....................................................................................................................................................
151
Chapter 10 Oncology： NonPositron Emission
Tomography
........................................................................ 152
PEPTIDE RECEPToR IMAGING
......................................................................................................................................
152
ADRENAl SCINTIGRAPHY
.............................................................................................................................................
154
MoNoCloNAl ANTIBoDY IMAGING AND THERAPY
.........................................................................................
156
NoNSPECIFIC BINDING TUMoR AGENTS
.................................................................................................................
160
lYMPHoSCINTIGRAPHY： THE SENTINEl lYMPH NoDE
....................................................................................
162
INTRAARTERIAl RADIoACTIvE MICRoSPHERES
..................................................................................................
164
BoNE PAIN PAllIATIoN
................................................................................................................................................
165
SUGGESTED READING
.....................................................................................................................................................
167
Chapter 11 Skeletal Scintigraphy
................................................................................................................................
169
BoNE SCAN
.........................................................................................................................................................................
169
ClINICAl APPlICATIoN oF SkElETAl
SCINTIGRAPHY
.....................................................................................
176
BoNE INFARCTIoN AND oSTEoNECRoSIS
..............................................................................................................
191
oSTEoMYElITIS
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193
FloURINE-18 SoDIUM FlUoRIDE PoSITRoN
EMISSIoN ToMoGRAPHY ....................................................... 196
BoNE MINERAl MEASUREMENT
................................................................................................................................
197
SUGGESTED READING
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198
Chapter 12 Pulmonary System
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199
PUlMoNARY EMBolISM
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199
vENTIlATIoN PERFUSIoN SCINTIGRAPHY
.............................................................................................................
199
RADIoPHARMACEUTICAlS
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200
IMAGE INTERPRETATIoN
..............................................................................................................................................
203
vENTIlATIoN-PERFUSIoN INTERPRETATIoN CRITERIA
....................................................................................
207
oTHER ADDITIoNAl vQ INTERPRETATIoN
CRITERIA
.....................................................................................
212
SUGGESTED READING .....................................................................................................................................................
212
Chapter 13 Infection and Inflammation
...................................................................................................................
213
RADIoPHARMACEUTICAlS
..........................................................................................................................................
213
ClINICAl APPlICATIoNS FoR INFECTIoN
SCINTIGRAPHY
..............................................................................
218
SUGGESTED READING
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226
Chapter 14 Gastrointestinal System
...........................................................................................................................
227
ESoPHAGEAl MoTIlITY ................................................................................................................................................
227
GASTRoESoPHAGEAl REFlUX DISEASE
..................................................................................................................
230
GASTRIC MoTIlITY SCINTIGRAPHY
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231
INTESTINAl TRANSIT SCINTIGRAPHY
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237
PRoTEIN-loSING ENTERoPATHY
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239
HElICoBACTER PYloRI INFECTIoN
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239
GASTRoINTESTINAl BlEEDING
..................................................................................................................................
239
HETERoToPIC GASTRIC MUCoSA
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245
SUGGESTED READING .....................................................................................................................................................
248
Chapter 15 Hepatobiliary System
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249
CHolESCINTIGRAPHY
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249
TECHNETIUM-99M RED BlooD CEll lIvER SCINTIGRAPHY
............................................................................
267
TECHNETIUM-99M SUlFUR ColloID lIvER AND
SPlEEN IMAGING ............................................................ 270
SPlEEN SCINTIGRAPHY
..................................................................................................................................................
272
TECHNETIUM-99M MACRoAGGREGATED AlBUMIN
HEPATIC ARTERIAl PERFUSIoN
SCINTIGRAPHY
.............................................................................................................................................................
274
SUGGESTED READING
.....................................................................................................................................................
275
Chapter 16 Genitourinary System
..............................................................................................................................
277
RENAl ANAToMY AND FUNCTIoN
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277 RENAl RADIoPHARMACEUTICAlS
...........................................................................................................................
278 DYNAMIC RENAl IMAGING TECHNIQUES
..............................................................................................................
283 MEASURING RENAl FUNCTIoN：EFFECTIvE RENAl PlASMA FloWERPFAND GloMERUlAR
FIlTRATIoN RATE GFR
............................................................................................................................................
292
RENAl CoRTICAl IMAGING
.........................................................................................................................................
292
SUGGESTED READING
.....................................................................................................................................................
294
Part Ⅲ Radionuclide
Therapy Chapter 17 Nuclear Medicine Therapy
....................................................................................................................
297
RADIoIoDINE THEARPY FoR HYPERTHYRoIDISM
...............................................................................................
297
MANAGEMENT oF HYPERTHYRoIDISM DUE To ToXIC
MUlTINoDUlAR GoITER AND ToXIC
ADENoMA
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300
MANAGEMENT oF GD IN CHIlDREN AND
ADolESCENTS
...............................................................................
301
CANCER RISk AND RADIATIoN SAFETY REGARDING
RADIoIoDINE THEARPY FoR
HYPERTHYRoIDISM
....................................................................................................................................................
301
RADIoIoDINE THERAPY FoR THYRoID CANCER
.................................................................................................
302
METASTATIC BoNE PAIN THERAPY
...........................................................................................................................
309
SUGGESTED READING
.....................................................................................................................................................
311
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| 內容試閱：
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The applications of Nuclear Medicine in
different medical disciplines have kept increasing in the past several decades.
As an important part of molecular imaging, SPECTCT and PET CT have become
commonly used in Nuclear Medicine imaging modality. Nuclear Medicine, as an
important medical knowledge, has been independently and widely learned by
medical students including overseas students. More and more overseas students
come to China to learn medicine in recent years. Most of them apply for
Bachelor degree. It is necessary to edit an English textbook of Nuclear
Medicine for the undergraduate program. Physicians from Nuclear Medicine
department of Tianjin Medical University General Hospital have been devoted to
Nuclear Medicine education since the 1980s. Supported and organized by Tsinghua
University Press and Tianjin Medical University, twelve Nuclear Medicine
experts and scholars from nine universities in China make contributions to this
textbook, which is based on Nuclear Medicine The requisitesedition 4 written
by Harvey A. Ziessman MD and published by Saunders.
In order to meet the basic needs of both
international and domestic medical students, necessary adaptations and
revisions are carefully made from the original book. In addition, we reorganize
the chapters and make a new chapter of radionuclide therapy in order to give
students a systemic knowledge in this field. This new textbook covers three
parts, including Basic Principles, Clinical Nuclear Medicine and Radionuclide
Therapy. The chapters follow an outline format and the main section Clinical
Nuclear Medicine are divided by organ-systems i.e., Central Nervous System,
Cardiac System, Endocrine System, etc.
Although this edition is primarily designed
for overseas medical students, it is also a good reference book for Nuclear
Medicine physicians and technicians, resident doctors in other specialties. We
hope it is helpful to all the readers. We would like to share our limited
knowledge and experience with the readers. Comments and suggestions for this
book are always welcome.
In compiling this book, we received
assistance from many sources, and would like to thank those people for their
supports.
Editors July 8,2017
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