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| 內容簡介： |
The bestselling introduction to bioinformatics and functional
genomics—now in an updated edition
Widely received in its previous edition, Bioinformatics and
Functional Genomics offers the most broad-based introduction to
this explosive new discipline. Now in a thoroughly updated and
expanded Second Edition, it continues to be the go-to source for
students and professionals involved in biomedical research.
This edition provides up-to-the-minute coverage of the fields of
bioinformatics and genomics. Features new to this edition
include:
Several fundamentally important proteins, such as globins,
histones, insulin, and albumins, are included to better show how to
apply bioinformatics tools to basic biological questions.
A completely updated companion web site, which will be updated as
new information becomes available - visit
www.wiley.comgopevsnerbioinformatics
Descriptions of genome sequencing projects spanning the tree of
life.
A stronger focus on how bioinformatics tools are used to
understand human disease.
The book is complemented by lavish illustrations and more than
500 figures and tables—fifty of which are entirely new to this
edition. Each chapter includes a Problem Set, Pitfalls, Boxes
explaining key techniques and mathematicsstatistics principles,
Summary, Recommended Reading, and a list of freely available
software. Readers may visit a related Web page for supplemental
information at www.wiley.comgopevsnerbioinformatics.
Bioinformatics and Functional Genomics, Second Edition serves as
an excellent single-source textbook for advanced undergraduate and
beginning graduate-level courses in the biological sciences and
computer sciences. It is also an indispensable resource for
biologists in a broad variety of disciplines who use the tools of
bioinformatics and genomics to study particular research problems;
bioinformaticists and computer scientists who develop computer
algorithms and databases; and medical researchers and clinicians
who want to understand the genomic basis of viral, bacterial,
parasitic, or other diseases.
Praise for the first edition:
"...ideal both for biologists who want to master the application
of bioinformatics to real-world problems and for computer
scientists who need to understand the biological questions that
motivate algorithms." Quarterly Review of Biology
"… an excellent textbook for graduate students and upper level
undergraduate students." Annals of Biomedical Engineering
"…highly recommended for academic and medical libraries, and for
researchers as an introduction and reference…" E-Streams
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| 目錄：
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Preface to the Second Edition.
Preface to the First Edition.
Foreword.
PART I ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN
DATABASES.
1 Introduction.
2 Access to Sequence Data and Literature Information.
3 Pairwise Sequence Alignment.
4 Basic Local Alignment Search Tool BLAST.
5 Advanced Database Searching.
6 Multiple Sequence Alignment.
7 Molecular Phylogeny and Evolution.
PART II GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.
8 Bioinformatic Approaches to Ribonucleic Acid RNA.
9 Gene Expression: Microarray Data Analysis.
10 Protein Analysis and Proteomics.
11 Protein Structure.
12 Functional Genomics.
PART III GENOME ANALYSIS.
13 Completed Genomes.
14 Completed Genomes: Viruses.
15 Completed Genomes: Bacteria and Archaea.
16 The Eukaryotic Chromosome.
17 Eukaryotic Genomes: Fungi.
18 Eukaryotic Genomes: From Parasites to Primates.
19 Human Genome.
20 Human Disease.
Glossary.
Answers to Self-Test Quizzes.
Author Index.
Subject Index.
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