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| 內容簡介： |
本书是在DG Rao《IntroductiOnto
BiochemicaIEngineering》第二版的基础上，经过编者重新组织、删减和修改出版的。主要供生物类专业低年级学生了解生物工程与技术专业的全貌，明晰后续专业课程之间的相互关系，领悟生物工程领域发展的现状和动态及其对社会和经济发展的影响，尤其是当今社会在面临着能源危机、资源危机和环境危机时生物技术所发挥的作用。阅读《生物工程导论英文改编版第2版》后，可提高学生对专业知识的理解，激发其进一步学习专业知识的兴趣和爱好。对于其他相关专业的学生则可拓展其视野、优化其知识结构、提高其科学素养。
本书既可作为高等院校生物工程、生物技术、化学工程、制药工程和环境工程等专业的导论教材，化学、生物和食品等专业的拓展教材，也可供相关学科从事教学、科研和生物产业管理者学习和参考。
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| 目錄：
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Chapter 1 Introduction to Bioprocessing Fundamentals 1
1.1 HISTORICAL DEVELOPMENTS OF BIOPROCESSING TECHNOLOGY 1
1.2 OVERVIEW OF TRADITIONAL AND MODEN APPLICATIONS OF
BIOTECHNOLOGY 3
1.3 INTERADISCIPLINARY APPROACH TO BIOPROGROCESSING 3
1.4 OUTLINES OF LINTEGRATED BIOPROCESS 4
1.5 UNIT OPERATIONS BIOPROCESS 6
References 7
Review Questions 7
Chapter 2 Overview of Microbiology 8
2.1 HISTORIC BACKGROUND 8
2.2 MICROSCOPY 10
2.3 MICROBIAL TAXONOMY 10
2.4 CHEMICAL COMPOSITION 13
2.5 NUTRITIONAL REQUIREMENTS 13
2.6 METABOLISM 15
2.7 PROCARYOTIC CELL 19
2.8 EUCARYOTIC CELL 22
2.9 VIRUSES 26
2.10 FUNGI 26
2.11 ALGAE 26
2.12 PROTOZOA 27
2.13 IMPORTANCE OF MICROBIOLOGY 27
2.14 CONCLUDING REMARKS 29
References 29
Review Questions 29
Chapter 3 Introduction to Biochemistry 31
3.1 LIPIDS 31
3.2 PROTEINS 36
3.3 CARBOHYDRATES 39
3.4 NUCLEIC ACIDS 43
3.5 VITAMINS 45
References 50
Review Questions 50
Chapter 4 Enzymes 51
4.1 HISTORY OF ENZYMES 51
4.2 CLASSIFICATION OF ENZYMES 51
4.3 ENZYMES AS BIOLOGICAL CATALYSTS 52
4.4 ENZYME SPECIFICITY 54
4.5 ENZYME KINETICS 56
4.6 IMMOBILIZATION OF ENZYMES 60
4.7 INDUSTRIAL APPLICATIONS OF ENZYMES 63
References 67
Review Questions 68
Chapter 5 Fermentation 69
5.1 GENERAL REQUIREMENTS OF FERMENTATION PROCESS 69
5.2 RANGE OF FERMENTATION PROCESS 70
5.3 DESIGN AND CONSTRUCTION OF FERMENTER 76
5.4 MEDIA DESIGN FOR FERMENTATION 78
5.5 STERILIZATION 84
5.6 AEROBIC AND ANAEROBIC FERMENTATION PROCESSES 90
5.7 SOLID STATE AND SUBMERGED FERMENTATION AND THEIR APPLICATIONS
91
5.8 VARIOUS TYPES OF BIOREACTORS 92
References 98
Review Questions 100
Chapter 6 Kinetics of Microbial Growth and Biochemical Reactors
101
6.1 PHASES OF CELL GROWTH 102
6.2 BATCH REACTOR DATA ANALYSIS 102
6.3 KINETIC MODELS FOR CELL GROWTH 107
6.4 GROWTH OF FILAMENTOUS ORGANISMS 112
6.5 SUBSTRATE AND PRODUCT INHIBITION ON CELL GROWTH 113
6.6 STRUCTURED MODELS 114
6.7 DESIGN EQUATIONS BASED ON BIOCHEMICAL REACTIONS 116
References 119
Review Questions 120
Problems 120
Chapter 7 Ideal Reactors 121
7.1 DESIGN OF IDEAL REACTORS 121
7.2 SINGLE REACTOR 124
7.3 MULTIPLE REACTORS 131
References 136
Review Questions 137
Problems 137
Chapter 8 Multiple Reactions 138
8.1 PARALLEL REACTIONS 139
8.2 SERIES REACTIONS 141
8.3 SERIES PARALLEL REACTIONS 145
8.4 DESIGN PRINCIPLES 147
References 149
Review Questions 149
Chapter 9 Heat Transfer in Bioprocessing 151
9.1 HEAT TRANSFER BY CONDUCTION 152
9.2 HEAT TRANSFER BY CONVECTION 159
9.3 HEAT TRANSFER BY RADIATION 171
References 176
Review Questions 177
Problems 177
Chapter 10 Mass Transfer in Bioprocessing Operations 179
10.1 MASS TRANSFER BY DIFFUSION 180
10.2 THEORIES OF DIFFUSIONAL MASS TRANSFER 180
10.3 MASS TRANSFER BY CONVECTION 183
10.4 OXYGEN TRANSFER METHODOLOGY IN FERMENTERS 191
10.5 FACTORS AFFECTING OXYGEN TRANSFER RATE 195
References 202
Review Questions 203
Problems 203
Chapter 11 Heterogeneous Reaction Systems 205
11.1 MASS TRANSFER CONSIDERATIONS 205
11.2 INTRA PARTICLE DIFFUSION AND REACTION RATE 208
11.3 EFFECTIVENESS FACTOR AND THIELE MODULUs 210
11.4 OBSERVABLE THIELE MODULUS 213
11.5 BIOREACTOR SELECTION CRITERIA 214
References 215
Review Questions 215
Chapter12 Bioreactors and Fermentation 217
12.1 BIOREACTORS 217
12.2 MONITORING AND CONTROL OF FERMENTATION PROCESSES 219
12.3 VARIOUS ACCESSORIES 224
12.4 CULTIVATION OF ORGANISMS 225
12.5 MEDIA OPTIMISATION 229
References 230
Review Questions 231
Chapter 13 Product Recovery 232
13.1 REMOVAL OF SUSPENDED SOLIDS 234
13.2 FILTRATION 234
13.3 SEDIMENTATION 241
13.4 CENTRIFUGATION 244
13.5 CELL DISRUPTION 248
13.6 EXTRACTION 249
13.7 MEMBRANE SEPARATION 252
13.8 CHROMATOGRAPHY 253
13.9 CRYSTALLISATION 256
13.10 DRYING 258
References 265
Review Questions 265
Chapter 14 Effluent Treatment 267
14.1 NEED FOR EFFLUENT TREATMENT 267
14.2 PHYSICAL METHODS 269
14.3 CHEMICAL METHODS 269
14.4 BIOLOGICAL METHODS 270
References 275
Review Questions 275
Chapter 15 Design and Analysis of Bioreactors 276
15.1 STABILITY AND ANALYSIS OF BIOREACTORS 277
15.2 DESIGN AND OPERATION OF BIOREACTORS 279
15.3 BIOREACTOR FOR PLANT AND ANIMAL CELLS 286
15.4 SCALE UP OF BIOREACTORS 289
15.5 SOME CRITERIA FOR SELECTION OF BIOREACTORS 293
References 295
Review Questions 296
Chapter 16 Bioprocess Economics 298
16.1 PLANTDESIGN AND ECONOMICS 300
16.2 COST OF PRODUCTION 303
16.3 BREAK EVEN ANALYSIS 305
16.4 PROJECT ECONOMICS 307
16.5 DEPRECIATION 310
16.6 PROJECT ECONOMICS FOR CITRIC ACID MANUFACTURE 311
References 319
Review Questions 319
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